Jenks, check here to see if this applies.
http://support.microsoft.com/default...b;en-us;315350


"Jenks318" <Jenks318@discussions.microsoft.com> wrote in message
news:AFE4B504-E1A3-4590-93EB-EB2D88F8DD32@microsoft.com...
> Windows XP Home SP2 with current antivirus and spyware scans.
> I have two cd drives that came with the computer. They have worked without
> any problems for 3 years. My wife opened her desktop that she had not
> used
> for months to install a program from cd. The firewall and Microsoft
> antispyware gave her options to block processes or applications. I
> believe
> she blocked two. Antispyware will not open to show blocked processes.
> Both
> cd drives show this message: E:\ is not accessible. Incorrect function.
> I
> disabled both the sygate firewall and antispyware, and rebooted with no
> change. I was able to open both cd drives and view the cds in safe mode.
> I
> uninstalled the firewall and antispyware with no change. I removed the
> two
> cd drives and Windows reinstalled them. The drivers are current. Device
> manager shows not conflicts or problems. The drives will not recognize
> any
> type of cd media unless in safe mode. I threw in a system restore against
> my
> better judgement when none of the above worked.